Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer.

ABSTRACT:

Background

Necroptosis is a novel type of programmed cell death distinct from apoptosis. However, the role of necroptosis in ovarian cancer (OC) remains unclear. The present study investigated the prognostic value of necroptosis-related genes (NRGs) and the immune landscape in OC.

Methods

The gene expression profiling and clinical information were downloaded from the TCGA and GTEx databases. Differentially expressed NRGs (DE-NRGs) between OC and normal tissueswere identified. The regression analyses were conducted to screen the prognostic NRGs and construct the predictive risk model. Patients were then divided into high- and low-risk groups, and the GO and KEGG analyses were performed to explore bioinformatics functions between the two groups. Subsequently, the risk level an

SUBMITTER: Nie S 

PROVIDER: S-EPMC10127035 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature