M5U-SVM: identification of RNA 5-methyluridine modification sites based on multi-view features of physicochemical features and distributed representation.

ABSTRACT: RNA 5-methyluridine (m5U) modifications are obtained by methylation at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is related to the development of human diseases. Accurate identification of m5U modification sites from RNA sequences can contribute to the understanding of their biological functions and the pathogenesis of related diseases. Compared to traditional experimental methods, computational methods developed based on machine learning with ease of use can identify modification sites from RNA sequences in an efficient and time-saving manner. Despite the good performance of these computational methods, there are some drawbacks and limitations. In this study, we have developed a novel predictor, m5U-SVM, based on multi-view features and machine lear

SUBMITTER: Ao C 

PROVIDER: S-EPMC10127088 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature