QT-Prolonging Antibiotics, Serum-to-Dialysate Potassium Gradient, and Risk of Sudden Cardiac Death Among Patients Receiving Maintenance Hemodialysis.

ABSTRACT:

Rationale & objective

Treatment with certain QT interval-prolonging antibiotics is associated with a higher risk of sudden cardiac death among individuals with hemodialysis-dependent kidney failure. Concurrent exposure to large serum-to-dialysate potassium gradients, which promote large potassium shifts, may augment the proarrhythmic effects of these medications. The primary objective of this study was to examine whether the serum-to-dialysate gradient modifies the cardiac safety of azithromycin, and separately, levofloxacin/moxifloxacin.

Study design

Retrospective observational cohort study using a new-user study design.

Setting & population

Adult in-center hemodialysis patients with Medicare coverage in the US Renal Data System (2007-2017).

Exposure

Initiatio

SUBMITTER: Pun PH 

PROVIDER: S-EPMC10127135 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature