Review and Update of Active and Passive Immunization Against Respiratory Syncytial Virus.

ABSTRACT: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection (LRTI) in children, causing approximately 3.6 million hospitalizations per year, and has been associated with long-term pulmonary sequelae for up to 30 years after infection, yet preventative strategies and active treatment options remain elusive. The associated morbidity and healthcare related costs could be decreased substantially with the development of these much-needed medications. After an initial false start in the development of an RSV vaccine, gradual progress is now being made with the development of multiple vaccine candidates using numerous different mechanisms of action. Furthermore, nirsevimab, a new monoclonal antibody for the prevention of RSV, has recently been registered in the

SUBMITTER: Verwey C 

PROVIDER: S-EPMC10127166 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature