Construction and evaluation of an aging-associated genes-based model for pancreatic adenocarcinoma prognosis and therapies.

ABSTRACT: Objectives: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor. Despite extensive research, the precise role of aging-related genes in the initiation, microenvironment regulation, and progression of PAAD remains unclear.Methods: Patients with PAAD were selected from the International Cancer Genome Consortium (ICGC), and The Cancer Genome Atlas (TCGA) cohorts and the cell senescence-associated genes were obtained from CellAge. ConsensusClusterPlus was utilized for cluster identification. The least absolute shrinkage and selection operator (LASSO) Cox regression analysis was performed to construct a prognosis prediction model.Results: We identified three clusters (C1, C2, and C3) based on aging-associated gene profiles. The C1 cluster had a shorter overall surv

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10127222 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature