Brain-targeted delivery of losartan through functionalized liposomal nanoparticles for management of neurogenic hypertension.

ABSTRACT: There is mounting experimental evidence that blocking angiotensin receptor type 1 activity can prevent the occurrence of hypertension in spontaneously hypertensive rats. Studies have proved this strategy via evasive means, such as intracerebrovascular injections, making clinical translation difficult. This study aimed to develop penetratin and transferrin functionalized liposomes as a delivery tool to safely deliver losartan potassium (an angiotensin receptor blocker) to the brain. Penetratin and transferrin functionalized losartan-loaded liposomes were prepared via the post-insertion technique. Losartan-loaded liposomes were cationic, approximately 150 nm in size, entrapping 66.8 ± 1.5% of losartan. All formulations were well tolerated and internalized by primary and cultured cells in 4 h

SUBMITTER: Lamptey RNL 

PROVIDER: S-EPMC10127229 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature