Charge-controlled Pd catalysis enables the meta-C-H activation and olefination of arenes.

ABSTRACT: The regioselective C-H activation of arenes remains one of the most promising techniques for accessing highly important functionalized motifs. Such functionalizations can generally be achieved through directed and non-directed processes. The directed approach requires a covalently attached directing group (DG) on the substrate to induce reactivity and selectivity and therefore intrinsically leaves a functional group at the point of attachment within the molecule, even after the tailored DG has been removed. Conversely, non-directed methods typically suffer from regioselectivity issues, especially for unbiased substrates. Herein, we report a unique approach that employs weak charge-charge and charge-dipole interactions to enable the meta-selective activation and olefination of arenes

SUBMITTER: Mondal A 

PROVIDER: S-EPMC10127283 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature