Prevalence, causes and impact of TP53-loss phenocopying events in human tumors.

ABSTRACT:

Background

TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity - which may occur due to alterations in trans - from gene expression patterns. Several such alterations that phenocopy p53 loss are known, however additional ones may exist, but their identity and prevalence among human tumors are not well characterized.

Results

We perform a large-scale statistical analysis on transcriptomes of ~ 7,000 tumors and ~ 1,000 cell lines, estimating that 12% and 8% of tumors and cancer cell lines, respectively, phenocopy TP53 loss: they are likely deficient in the activity of the p53 pathway, while not bearing obvious TP53 inactivating m

SUBMITTER: Fito-Lopez B 

PROVIDER: S-EPMC10127307 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature