Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis.

ABSTRACT:

Background

Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibitor 5 (Api5), an inhibitor of apoptosis, is upregulated in cancers. Interestingly, Api5 is shown to regulate both apoptosis and cell proliferation. To address the precise functional significance of Api5 in carcinogenesis here we investigate the role of Api5 in breast carcinogenesis.

Methods

Initially, we carried out in silico analyses using TCGA and GENT2 datasets to understand expression pattern of API5 in breast cancer patients followed by investigating the protein expression in Indian breast cancer patient samples. To investigate the functional importance

SUBMITTER: Kuttanamkuzhi A 

PROVIDER: S-EPMC10127332 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature