The role of DNA hydroxymethylation and TET enzymes in placental development and pregnancy outcome.

ABSTRACT: The placenta is a temporary organ that is essential for supporting mammalian embryo and fetal development. Understanding the molecular mechanisms underlying trophoblast differentiation and placental function may contribute to improving the diagnosis and treatment of obstetric complications. Epigenetics plays a significant role in the regulation of gene expression, particularly at imprinted genes, which are fundamental in the control of placental development. The Ten-Eleven-Translocation enzymes are part of the epigenetic machinery, converting 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). DNA hydroxymethylation is thought to act as an intermediate in the DNA demethylation mechanism and potentially be a stable and functionally relevant epigenetic mark on its own. The role of DN

SUBMITTER: Vasconcelos S 

PROVIDER: S-EPMC10127343 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature