Aspirin or statin use in relation to survival after surgery for esophageal cancer: a population-based cohort study.

ABSTRACT:

Background

Adjuvant postoperative treatment with aspirin and statins may improve survival in several solid tumors. This study aimed to assess whether these medications improve the survival after curatively intended treatment (including esophagectomy) for esophageal cancer in an unselected setting.

Methods

This nationwide cohort study included nearly all patients who underwent esophagectomy for esophageal cancer in Sweden from 2006 to 2015, with complete follow-up throughout 2019. Risk of 5-year disease-specific mortality in users compared to non-users of aspirin and statins was analyzed using Cox regression, providing hazard ratios (HR) with 95% confidence intervals (CI). The HRs were adjusted for age, sex, education, calendar year, comorbidity, aspirin/statin use (mutual ad

SUBMITTER: Holmberg D 

PROVIDER: S-EPMC10127395 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature