Robust classification of wound healing stages in both mice and humans for acute and burn wounds based on transcriptomic data.

ABSTRACT:

Background

Wound healing involves careful coordination among various cell types carrying out unique or even multifaceted functions. The abstraction of this complex dynamic process into four primary wound stages is essential to the study of wound care for timing treatment and tracking wound progression. For example, a treatment that may promote healing in the inflammatory stage may prove detrimental in the proliferative stage. Additionally, the time scale of individual responses varies widely across and within the same species. Therefore, a robust method to assess wound stages can help advance translational work from animals to humans.

Results

In this work, we present a data-driven model that robustly identifies the dominant wound healing stage using transcriptomic data from

SUBMITTER: Zlobina K 

PROVIDER: S-EPMC10127407 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature