Spatial navigation is associated with subcortical alterations and progression risk in subjective cognitive decline.

ABSTRACT:

Background

Subjective cognitive decline (SCD) may serve as a symptomatic indicator for preclinical Alzheimer's disease; however, SCD is a heterogeneous entity regarding clinical progression. We aimed to investigate whether spatial navigation could reveal subcortical structural alterations and the risk of progression to objective cognitive impairment in SCD individuals.

Methods

One hundred and eighty participants were enrolled: those with SCD (n = 80), normal controls (NCs, n = 77), and mild cognitive impairment (MCI, n = 23). SCD participants were further divided into the SCD-good (G-SCD, n = 40) group and the SCD-bad (B-SCD, n = 40) group according to their spatial navigation performance. Volumes of subcortical structures were calculated and compared among the four groups,

SUBMITTER: Chen Q 

PROVIDER: S-EPMC10127414 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature