Do Genetic Variants Modify the Effect of Smoking on Risk of Preeclampsia in Pregnancy?

ABSTRACT:

Objective

Maternal smoking is associated with as much as a 50% reduced risk of preeclampsia, despite increasing risk of other poor pregnancy outcomes that often co-occur with preeclampsia, such as preterm birth and fetal growth restriction. Researchers have long sought to understand whether this perplexing association is biologically based, or a result of noncausal mechanisms. We examined whether smoking-response genes modify the smoking-preeclampsia association to investigate potential biological explanations.

Study design

We conducted a nested case-control study within the Norwegian Mother, Father and Child Birth Cohort (1999-2008) of 2,596 mother-child dyads. We used family-based log-linear Poisson regression to examine modification of the maternal smoking-preeclampsia re

SUBMITTER: Bauer AE 

PROVIDER: S-EPMC10127527 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature