A Novel CovS Variant Harbored by a Colonization Strain Reduces Streptococcus pyogenes Virulence.

ABSTRACT: Streptococcus pyogenes, also known as group A Streptococcus, causes a wide variety of diseases ranging from mild noninvasive to severe invasive infections. To identify possible causes of colonization-to-invasive switches, we determined the genomic sequences of 10 isolates from five pairs each composed of an invasive strain and a carriage strain originating from five infectious clusters. Among them, one pair displayed a single-nucleotide difference in covS, encoding the sensor histidine kinase of the two-component CovRS system that controls the expression of 15% of the genome. In contrast to previously described cases where the invasive strains harbor nonfunctional CovS proteins, the carriage strain possessed the mutation covST115C, leading to the replacement of the tyrosine a

SUBMITTER: Plainvert C 

PROVIDER: S-EPMC10127592 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature