Ecological Stability Emerges at the Level of Strains in the Human Gut Microbiome.

ABSTRACT: The human gut microbiome harbors substantial ecological diversity at the species level as well as at the strain level within species. In healthy hosts, species abundance fluctuations in the microbiome are thought to be stable, and these fluctuations can be described by macroecological laws. However, it is less clear how strain abundances change over time. An open question is whether individual strains behave like species themselves, exhibiting stability and following the macroecological relationships known to hold at the species level, or whether strains have different dynamics, perhaps due to the relatively close phylogenetic relatedness of cocolonizing lineages. Here, we analyze the daily dynamics of intraspecific genetic variation in the gut microbiomes of four healthy, densely longitud

SUBMITTER: Wolff R 

PROVIDER: S-EPMC10127601 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature