Cerebral Malaria Is Regulated by Host-Mediated Changes in Plasmodium Gene Expression.

ABSTRACT: Cerebral malaria (CM), the deadliest complication of Plasmodium infection, is a complex and unpredictable disease. However, our understanding of the host and parasite factors that cause CM is limited. Using a mouse model of CM, experimental CM (ECM), we performed a three-way comparison between ECM-susceptible C57BL/6 mice infected with ECM-causing Plasmodium ANKA parasites [ANKA^(C57BL/6)], ECM-resistant BALB/c mice infected with Plasmodium ANKA [ANKA^(BALB/c)], and C57BL/6 mice infected with Plasmodium NK65 that does not cause ECM [NK65^(C57BL/6)]. All ANKA^(C57BL/6) mice developed CM. In contrast, in ANKA^(BALB/c) and NK65^(C57BL/6), infections do not result in CM and proceed similarly in terms of par

SUBMITTER: Cimperman CK 

PROVIDER: S-EPMC10127683 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature