MNK Proteins as Therapeutic Targets in Leukemia.
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ABSTRACT:
SUBMITTER: Mazewski C
PROVIDER: S-EPMC10128080 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
MNK Proteins as Therapeutic Targets in Leukemia.
Mazewski Candice C Platanias Leonidas C LC
OncoTargets and therapy 20230421
In leukemia, resistance to therapy is a major concern for survival. MAPK-interacting kinases (MNKs) have been identified as important activators of oncogenic-related signaling and may be mediators of resistance. Recent studies in leukemia models, especially acute myeloid leukemia (AML), have focused on targeting MNKs together with other inhibitors or treating chemotherapy-resistant cells with MNK inhibitors. The preclinical demonstrations of the efficacy of MNK inhibitors in these combination fo ...[more]
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