Improving Lung Cancer Diagnosis with CT Radiomics and Serum Histoplasmosis Testing.

ABSTRACT:

Background

Indeterminate pulmonary nodules (IPN) are a diagnostic challenge in regions where pulmonary fungal disease and smoking prevalence are high. We aimed to determine the impact of a combined fungal and imaging biomarker approach compared with a validated prediction model (Mayo) to rule out benign disease and diagnose lung cancer.

Methods

Adults ages 40 to 90 years with 6-30 mm IPNs were included from four sites. Serum samples were tested for histoplasmosis IgG and IgM antibodies by enzyme immunoassay and a CT-based risk score was estimated from a validated radiomic model. Multivariable logistic regression models including Mayo score, radiomics score, and IgG and IgM histoplasmosis antibody levels were estimated. The areas under the ROC curves (AUC) of the models were

SUBMITTER: Marmor HN 

PROVIDER: S-EPMC10128087 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature