Diverse Mechanisms of Helicase Loading during DNA Replication Initiation in Bacteria.

ABSTRACT: Initiation of DNA replication is required for cell viability and passage of genetic information to the next generation. Studies in Escherichia coli and Bacillus subtilis have established ATPases associated with diverse cellular activities (AAA+) as essential proteins required for loading of the replicative helicase at replication origins. AAA+ ATPases DnaC in E. coli and DnaI in B. subtilis have long been considered the paradigm for helicase loading during replication in bacteria. Recently, it has become increasingly clear that most bacteria lack DnaC/DnaI homologs. Instead, most bacteria express a protein homologous to the newly described DciA (dnaC/dnaI antecedent) protein. DciA is not an ATPase, and yet it serves as a helicase oper

SUBMITTER: Blaine HC 

PROVIDER: S-EPMC10128896 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature