Vascular stiffening and endothelial dysfunction in atherosclerosis.

ABSTRACT:

Purpose of review

Aging is an important risk factor for cardiovascular disease and is associated with increased vessel wall stiffness. Pathophysiological stiffening, notably in arteries, disturbs the integrity of the vascular endothelium and promotes permeability and transmigration of immune cells, thereby driving the development of atherosclerosis and related vascular diseases. Effective therapeutic strategies for arterial stiffening are still lacking.

Recent findings

Here, we overview the literature on age-related arterial stiffening, from patient-derived data to preclinical in-vivo and in-vitro findings. First, we overview the common techniques that are used to measure stiffness and discuss the observed stiffness values in atherosclerosis and aging. Next, the endothelial

SUBMITTER: Hooglugt A 

PROVIDER: S-EPMC10128901 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature