Case-only exome variation analysis of severe alcohol dependence using a multivariate hierarchical gene clustering approach.

ABSTRACT:

Background

Variation in genes involved in ethanol metabolism has been shown to influence risk for alcohol dependence (AD) including protective loss of function alleles in ethanol metabolizing genes. We therefore hypothesized that people with severe AD would exhibit different patterns of rare functional variation in genes with strong prior evidence for influencing ethanol metabolism and response when compared to genes not meeting these criteria.

Objective

Leverage a novel case only design and Whole Exome Sequencing (WES) of severe AD cases from the island of Ireland to quantify differences in functional variation between genes associated with ethanol metabolism and/or response and their matched control genes.

Methods

First, three sets of ethanol related genes were iden

SUBMITTER: Gentry AE 

PROVIDER: S-EPMC10128939 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature