Delayed skeletal muscle repair following inflammatory damage in simulated agent-based models of muscle regeneration.

ABSTRACT: Healthy skeletal muscle undergoes repair in response to mechanically localised strains during activities such as exercise. The ability of cells to transduce the external stimuli into a cascade of cell signalling responses is important to the process of muscle repair and regeneration. In chronic myopathies such as Duchenne muscular dystrophy and inflammatory myopathies, muscle is often subject to chronic necrosis and inflammation that perturbs tissue homeostasis and leads to non-localised, widespread damage across the tissue. Here we present an agent-based model that simulates muscle repair in response to both localised eccentric contractions similar to what would be experienced during exercise, and non-localised widespread inflammatory damage that is present in chronic disease. Computation

SUBMITTER: Khuu S 

PROVIDER: S-EPMC10128985 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature