Transplacental transfer of Lassa IgG antibodies in pregnant women in Southern Nigeria: A prospective hospital-based cohort study.

ABSTRACT:

Background

Evidence from previous studies suggest that Lassa fever, a viral haemorrhagic fever endemic to West Africa has high case fatalities, particularly in pregnancy. While there have been remarkable innovations in vaccine development, with some Lassa vaccines undergoing early clinical trials. An understanding of Lassa antibody kinetics and immune responses will support vaccine design and development. However, there is currently no evidence on the antibody kinetics of Lassa (LASV) in pregnancy. Our study sought to estimate the efficiency of transplacental transfer of LASV IgG antibodies from the mother to the child.

Methodology/principal findings

The study made use of data from a prospective hospital-based cohort of pregnant women enrolled at the antenatal clinic and fol

SUBMITTER: Kayem ND 

PROVIDER: S-EPMC10129015 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature