Single-cell transcriptomic analysis of tumor heterogeneity and intercellular networks in human urothelial carcinoma.

ABSTRACT:

Background

Heterogeneity of tumor cells and the tumor microenvironment (TME) is significantly associated with clinical outcomes and treatment responses in patients with urothelial carcinoma (UC). Comprehensive profiling of the cellular diversity and interactions between malignant cells and TME may clarify the mechanisms underlying UC progression and guide the development of novel therapies. This study aimed to extend our understanding of intra-tumoral heterogeneity and the immunosuppressive TME in UC and provide basic support for the development of novel UC therapies.

Methods

Seven patients with UC were included who underwent curative surgery at our hospital between July 2020 and October 2020. We performed single-cell RNA sequencing (scRNA-seq) analysis in seven tumors with

SUBMITTER: Jin X 

PROVIDER: S-EPMC10129232 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature