Proteomics analysis of coronary blood microparticles in patients with acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is the leading cause of death for patients with cardiovascular disease (CVD). Although researchers have made substantial efforts to elucidate its pathogenesis, the molecular mechanisms underlying AMI remain unknown. The aim of this study was to use proteomics to identify differentially expressed proteins (DEPs) and the possible biological functions and metabolic pathways related to coronary blood microparticles (MPs) in patients with AMI and stable coronary artery disease (SCAD); this study will allow for the identification of individuals at risk of acute thrombosis.

Methods

The study was performed on 5 AMI patients and 5 SCAD patients. DEPs were identified, and Gene Ontology (GO) enrichment and KEGG pathway enrichment analyzes we

SUBMITTER: Ma Y 

PROVIDER: S-EPMC10129261 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature