Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer's disease.

ABSTRACT:

Objective

Remembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer's disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer's disease dementia before mild clinical decline is detectable.

Method

We compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer's disease-associated apolipoprotein E e4 allele (APOE4; n = 39) to demographically and neuropsychologically similar non-APOE4 carriers (n = 43).

Results

APOE4 carriers showed a significant reduction for episodic details when remembering past events (

SUBMITTER: Acevedo-Molina MC 

PROVIDER: S-EPMC10129290 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature