Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells.

ABSTRACT: Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over 30 mitochondrial deafness genes, and mitochondria are implicated in hair cell death following noise exposure, aminoglycoside antibiotic exposure, as well as in age-related hearing loss. However, little is known about the basic aspects of hair cell mitochondrial biology. Using hair cells from the zebrafish lateral line as a model and serial block-face scanning electron microscopy, we have quantifiably characterized a unique hair cell mitochondrial phenotype that includes (1) a high mitochondrial volume and (2) specific mitochondrial architecture: multiple small mitochondria apically, and a reticular mitochondria

SUBMITTER: McQuate A 

PROVIDER: S-EPMC10129330 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature