Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults.

ABSTRACT:

Background

The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster.

Methods

During a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization of SARS-CoV-2 (n = 87). In parallel, cellular immunity (n = 45) was analyzed in stimulated peripheral mononuclear cells by flow cytometry and ELISPOT.

Findings

Although a 2.5-fold increase in neutralization of the ancestral SARS-CoV-2 was observed after the secon

SUBMITTER: Mendez C 

PROVIDER: S-EPMC10129368 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature