First-in-human neuroimaging of soluble epoxide hydrolase using [¹⁸F]FNDP PET.

ABSTRACT:

Purpose

Soluble epoxide hydrolase (sEH) is an enzyme with putative effect on neuroinflammation through its influence on the homeostasis of polyunsaturated fatty acids and related byproducts. sEH is an enzyme that metabolizes anti-inflammatory epoxy fatty acids to the corresponding, relatively inert 1,2-diols. A high availability or activity of sEH promotes vasoconstriction and inflammation in local tissues that may be linked to neuropsychiatric diseases. We developed [¹⁸F]FNDP to study sEH in vivo with positron emission tomography (PET).

Methods

Brain PET using bolus injection of [¹⁸F]FNDP followed by emission imaging lasting 90 or 180 min was completed in healthy adults (5 males, 2 females, ages 40-53 years). The kinetic behavior of [¹⁸F]FND

SUBMITTER: Coughlin JM 

PROVIDER: S-EPMC10129439 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature