Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI.

ABSTRACT:

Background

New daily persistent headache (NDPH) is a rare but debilitating primary headache disorder that poses a significant burden on individuals and society. Despite its clinical importance, the underlying pathophysiological mechanisms of NDPH remain unclear. In this study, we aimed to investigate the brain structural changes and neural activity patterns in patients with NDPH using multimodal brain imaging analysis of structural magnetic resonance imaging (sMRI) combined with magnetoencephalography (MEG).

Methods

Twenty-eight patients with NDPH and 37 healthy controls (HCs) were recruited for this study, and their structural and resting-state data were collected by 3.0 Tesla MRI and MEG. We analyzed the brain morphology using voxel-based morphometry and source-based morph

SUBMITTER: Qiu D 

PROVIDER: S-EPMC10129440 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature