Advanced pathophysiology mimicking lung models for accelerated drug discovery.

ABSTRACT:

Background

Respiratory diseases are the 2nd leading cause of death globally. The current treatments for chronic lung diseases are only supportive. Very few new classes of therapeutics have been introduced for lung diseases in the last 40 years, due to the lack of reliable lung models that enable rapid, cost-effective, and high-throughput testing. To accelerate the development of new therapeutics for lung diseases, we established two classes of lung-mimicking models: (i) healthy, and (ii) diseased lungs - COPD.

Methods

To establish models that mimic the lung complexity to different extents, we used five design components: (i) cell type, (ii) membrane structure/constitution, (iii) environmental conditions, (iv) cellular arrangement, (v) substrate, matrix structure and composit

SUBMITTER: Phan TH 

PROVIDER: S-EPMC10129441 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature