Individual-Based Modeling of Spatial Dynamics of Chemotactic Microbial Populations.

ABSTRACT: One important direction of synthetic biology is to establish desired spatial structures from microbial populations. Underlying this structural development process are different driving factors, among which bacterial motility and chemotaxis serve as a major force. Here, we present an individual-based, biophysical computational framework for mechanistic and multiscale simulation of the spatiotemporal dynamics of motile and chemotactic microbial populations. The framework integrates cellular movement with spatial population growth, mechanical and chemical cellular interactions, and intracellular molecular kinetics. It is validated by a statistical comparison of single-cell chemotaxis simulations with reported experiments. The framework successfully captures colony range expansion of growing i

SUBMITTER: Ni C 

PROVIDER: S-EPMC10129442 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature