Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma.

ABSTRACT:

Purpose

In recent years the tumor microenvironment and its interaction with the tumor has emerged into research focus with increased attention to the composition of Tumor-infiltrating lymphocytes. We wanted to quantify the composition of Regulatory T cells (Tregs) and T helper 17 cells (Th17 cells) and their prognostic impact in high-grade serous tubo-ovarian carcinoma.

Methods

Tregs and Th17 cells were determined by immunohistochemical analysis of CD25 FoxP3 and RORγt, respectively on tissue microarrays of a cohort of 222 patients with reviewed histology and available clinical data. Expression was analyzed with Qupath for quantification and integration with clinical data enabled calculation of prognostic impact. For validation FOXP3 and RORC mRNA expression levels from 502

SUBMITTER: Marchenko S 

PROVIDER: S-EPMC10129928 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature