Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer

ABSTRACT: Studying the cellular geographic distribution in non-small cell lung cancer is essential to understand the roles of cell populations in this type of tumor. In this study, we characterize the spatial cellular distribution of immune cell populations using 23 makers placed in five multiplex immunofluorescence panels and their associations with clinicopathologic variables and outcomes. Our results demonstrate two cellular distribution patterns—an unmixed pattern mostly related to immunoprotective cells and a mixed pattern mostly related to immunosuppressive cells. Distance analysis shows that T-cells expressing immune checkpoints are closer to malignant cells than other cells. Combining the cellular distribution patterns with cellular distances, we can identify four groups related to inflamed

SUBMITTER: Parra E 

PROVIDER: S-EPMC10130161 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature