Neoadjuvant therapy with Disitamab vedotin in treating muscle-invasive bladder cancer: A case report.

ABSTRACT:

Purpose

Platinum-based regimens are regarded as the preferred alternative for neoadjuvant chemotherapy for muscle-invasive bladder cancer (MIBC) patients. However, some patients cannot tolerate platinum-based regimens. We report an MIBC case with severe renal insufficiency treated by neoadjuvant therapy with gemcitabine and Disitamab Vedotin.

Materials and methods

A 68-year-old man with severe renal insufficiency was admitted to our department and diagnosed with cT3N0M0 MIBC. Immunohistochemical staining of the biopsy tissues showed human epidermal growth factor receptor 2 expression (1+). This patient received neoadjuvant therapy with gemcitabine 1600 mg and DV 120 mg intravenously every three weeks 3 times. We compared the imaging results of the patient before and after ne

SUBMITTER: Huang H 

PROVIDER: S-EPMC10130214 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature