Electroconvulsive therapy induces remodeling of hippocampal co-activation with the default mode network in patients with depression.

ABSTRACT:

Introduction

Electroconvulsive therapy (ECT) is a highly efficient treatment for depression. Previous studies repeatedly reported an ECT-induced volume increase in the hippocampi. We assume that this also affects extended hippocampal networks. This study aims to investigate the structural and functional interplay between hippocampi, hippocampal pathways and core regions of the default mode network (DMN). Twenty patients with a current depressive episode receiving ECT-treatment and twenty age and sex matched healthy controls (HC) were included in the study. ECT-patients underwent multimodal magnetic resonance imaging (MRI)-scans (diffusion weighted imaging, resting state functional MRI) before and after an ECT-index series. HC were also scanned twice in a similar between-scan time-i

SUBMITTER: Denier N 

PROVIDER: S-EPMC10130338 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature