Growth hormone secretagogues modulate inflammation and fibrosis in <i>mdx</i> mouse model of Duchenne muscular dystrophy.

ABSTRACT:

Introduction

Growth hormone secretagogues (GHSs) exert multiple actions, being able to activate GHS-receptor 1a, control inflammation and metabolism, to enhance GH/insulin-like growth factor-1 (IGF-1)-mediated myogenesis, and to inhibit angiotensin-converting enzyme. These mechanisms are of interest for potentially targeting multiple steps of pathogenic cascade in Duchenne muscular dystrophy (DMD).

Methods

Here, we aimed to provide preclinical evidence for potential benefits of GHSs in DMD, via a multidisciplinary in vivo and ex vivo comparison in mdx mice, of two ad hoc synthesized compounds (EP80317 and JMV2894), with a wide but different profile. 4-week-old mdx mice were treated for 8 weeks with EP80317 or JMV2894 (320 µg/kg/d, s.

SUBMITTER: Boccanegra B 

PROVIDER: S-EPMC10130389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature