Tissue-specific expansion of Zika virus isogenic variants drive disease pathogenesis.

ABSTRACT:

Background

The Asian lineage Zika virus (ZIKV) emerged as a public health emergency in 2016 causing severe neurological pathologies with no apparent historical correlate to the mild, disease-causing innocuous member of the mosquito-borne flavivirus genus that was discovered in Africa in 1947. Replication error rate of RNA viruses combined with viral protein/RNA structural plasticity can lead to evolution of virus-induced pathogenicity that is critical to identify and validate.

Methods

Infection studies in cells and A129 interferon alpha/beta receptor deficient mice with ZIKV French Polynesian H/PF/2013 clinical isolate, plaque-purified isogenic clone derivatives as well as infectious cDNA clone derived wild-type and site-specific mutant viruses, were employed together with N

SUBMITTER: Chan KWK 

PROVIDER: S-EPMC10130475 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature