Online control of the False Discovery Rate in group-sequential platform trials.

ABSTRACT: When testing multiple hypotheses, a suitable error rate should be controlled even in exploratory trials. Conventional methods to control the False Discovery Rate assume that all p-values are available at the time point of test decision. In platform trials, however, treatment arms enter and leave the trial at different times during its conduct. Therefore, the actual number of treatments and hypothesis tests is not fixed in advance and hypotheses are not tested at once, but sequentially. Recently, for such a setting the concept of online control of the False Discovery Rate was introduced. We propose several heuristic variations of the LOND procedure (significance Levels based On Number of Discoveries) that incorporate interim analyses for platform trials, and study their online False

SUBMITTER: Zehetmayer S 

PROVIDER: S-EPMC10130539 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature