Histaminergic neurotransmission in aging and Alzheimer's disease: A review of therapeutic opportunities and gaps.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a progressive neurodegenerative disorderfeaturing a brain accumulation of extracellular β-amyloidplaques (Aβ) and intracellular neurofibrillary tautangles (NFTs). Although cognitive decline is a disease-defining symptom of AD, sleep dysfunction, a common symptom often preceding cognitive decline, hasrecently gained more attention as a core AD symptom. Polysomnography and othersleep measures show sleep fragmentation with shortening of N₃ sleep togetherwith excessive daytime sleepiness (EDS) and sundowning as the main findings in AD patients. The latter reflects dysfunction of the wake-promoting neurons (WPNs), including histaminergic neurons (HA^N) located in thetuberomammillary nucleus (TMN) of the posterior hypothalamus

SUBMITTER: Satpati A 

PROVIDER: S-EPMC10130560 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature