High-dose vitamin D₃ supplementation in relapsing-remitting multiple sclerosis: a randomised clinical trial.

ABSTRACT:

Background

Vitamin D insufficiency is associated with risk of multiple sclerosis (MS) relapse; whether supplementation influences prognosis is unknown. The Vitamin D to Ameliorate MS (VIDAMS) trial aimed to determine if high dose (5000 International Units (IU)/day) versus low dose (600 IU/day) vitamin D_3, added to daily glatiramer acetate (GA), reduced the risk of clinical relapse in people with established relapsing remitting MS (RRMS) over 96 weeks.

Methods

VIDAMS is a randomised, phase 3, double-blind, multi-centre, controlled trial conducted at sixteen neurology clinics in the United States. Participants with MAGNIMS 2010 RRMS, aged 18-50 years, with recent disease activity were eligible to enroll if they had an Expanded Disability Status Scale score ≤4.0; min

SUBMITTER: Cassard SD 

PROVIDER: S-EPMC10130605 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature