Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8⁺ T cells in HIV infection.

ABSTRACT:

Background

CD8⁺ T cells equipped with a full arsenal of antiviral effector functions are critical for effective immune control of HIV-1. It has nonetheless remained unclear how best to elicit such potent cellular immune responses in the context of immunotherapy or vaccination. HIV-2 has been associated with milder disease manifestations and more commonly elicits functionally replete virus-specific CD8⁺ T cell responses compared with HIV-1. We aimed to learn from this immunological dichotomy and to develop informed strategies that could enhance the induction of robust CD8⁺ T cell responses against HIV-1.

Methods

We developed an unbiased in vitro system to compare the de novo induction of antigen-specific CD8⁺ T cell responses after

SUBMITTER: Cabral-Piccin MP 

PROVIDER: S-EPMC10130611 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature