Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system.

ABSTRACT:

Introduction

Narcolepsy type 1 (NT1) is a rare, chronic and disabling neurological disease causing excessive daytime sleepiness and cataplexy. NT1 is characterized pathologically by an almost complete loss of neurons producing the orexin neuropeptides in the lateral hypothalamus. Genetic and environmental factors strongly suggest the involvement of the immune system in the loss of orexin neurons. The cerebrospinal fluid (CSF), secreted locally and surrounding the central nervous system (CNS), represents an accessible window into CNS pathological processes.

Methods

To gain insight into the biological and molecular changes in NT1 patients, we performed a comparative proteomics analysis of the CSF from 21 recent-onset NT1 patients and from two control groups: group 1 with somat

SUBMITTER: Ayoub I 

PROVIDER: S-EPMC10130643 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature