SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress.

ABSTRACT: Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To study retinal degeneration, sodium iodate (NaIO₃) has been used to cause oxidative stress-induced RPE death followed by photoreceptor degeneration. However, analyses of RPE damage itself are still limited. Here, we characterized NaIO₃-induced RPE damage, which was divided into three regions: periphery with normal-shaped RPE, transitional zone with elongated cells, and center with severely damaged or lost RPE. Elongated cells in the transitional zone exhibited molecular characteristics of epithelial-mesenchymal transition. Central RPE was more susceptible to stresses than peripheral RPE. Under stresses, SIRT6, an NAD⁺-dependent protein deacylase, rapidly translocated

SUBMITTER: Yang X 

PROVIDER: S-EPMC10130745 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature