In-silico prediction of highly promising natural fungicides against the destructive blast fungus Magnaporthe oryzae.

ABSTRACT: Magnaporthe oryzae causes destructive blast disease in more than 50 species of the major cereal crops rice, wheat and maize and destroys food of millions of people worldwide. Application of synthetic chemical fungicides are environmentally hazardous and unreliable in controlling M. oryzae. Conversely, naturally occurring biofungicides with multiple modes of actions are needed to be discovered for combatting the blast fungus. To find the effective biofungicides, we performed molecular docking study of some potential antifungal natural compounds targeting two proteins including a single-stranded DNA binding protein MoSub1 (4AGH), and an effector protein AVR-Pik (5E9G) of M. oryzae that regulates transcription in fungus and/or suppresses the host cell immunity. The

SUBMITTER: Al Mamun Khan MA 

PROVIDER: S-EPMC10130775 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature