Mechanisms of type 2 diabetes resolution after Roux-en-Y gastric bypass.

ABSTRACT:

Background

Bariatric surgery is the most effective treatment for the reduction of weight and resolution of type 2 diabetes mellitus (T2 DM). The objective of this study was to longitudinally assess hormonal and tissue responses after RYGB.

Methods

Eight patients (5 with T2 DM) were studied before and after RYGB. A standardized test meal (STM) was administered before and at 1, 3, 6, 9, 12, and 15 months. Separately, a 2-hour hyperinsulinemic-euglycemic clamp (E-clamp) and a 2-hour hyperglycemic clamp (H-clamp) were performed before and at 1, 3, 6, and 12 months. Glucagon-like peptide-1 (GLP-1) was infused during the last hour of the H-clamp. Body composition was assessed with DXA methodology.

Results

Enrollment body mass index was 49±3 kg/m(2) (X±SE). STM glucose and i

SUBMITTER: Elahi D 

PROVIDER: S-EPMC10131082 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature