Drug-drug interactions between direct oral anticoagulants and anticonvulsants and clinical outcomes: A systematic review.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) are widely used in patients with atrial fibrillation and venous thromboembolism. However, DOACs have important potential drug-drug interactions (DDIs) with several classes of drugs. In particular, antiepileptic (AE) drugs may induce cytochrome P450 3A4 or P-glycoprotein. Co-administration of DOACs and AE drugs may result in lower DOAC drug levels and reduced DOAC efficacy. However, the clinical significance of such DDIs is uncertain.

Objectives

The aim of this systematic review was to generate an updated review of these DDIs and their clinical relevance, given the rapidly evolving knowledge relating to DOAC and AE DDIs.

Methods

We searched the MEDLINE and Embase databases for studies reporting clinical adverse outcomes (th

SUBMITTER: Candeloro M 

PROVIDER: S-EPMC10131112 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature