ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer.

ABSTRACT: For advanced, refractory endometrial cancer (EC), it is advisable to find effective immunotherapeutic targets. In the present study, genes affecting the immune status of uterine corpus endometrial carcinoma (UCEC) samples within The Cancer Genome Atlas were explored by weighted correlation network analysis and differential gene expression analysis. The protein function and immune correlation of 14 key genes, including ζ-chain-associated protein kinase 70 (ZAP70), were analyzed. Based on the expression levels of key genes, the patients with UCEC were divided into two groups using consensus clustering, low expression (group 1) and high expression (group 2). Next, the functions of differentially expressed genes (DEGs) between the two groups were identified using Gene Ontology enrichment analy

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10131270 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature