Regeneration of the heart: from molecular mechanisms to clinical therapeutics.

ABSTRACT: Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden. Military personnel, compared with civilians, is exposed to more stress, a risk factor for heart diseases, making cardiovascular health management and treatment innovation an important topic for military medicine. So far, medical intervention can slow down cardiovascular disease progression, but not yet induce heart regeneration. In the past decades, studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury. Insights have emerged from studies in animal models and early clinical trial

SUBMITTER: Guo QY 

PROVIDER: S-EPMC10131330 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature